April 24, 2020
It is your high school's policy that will govern the way that your overall GPA is computed. Some high schools include grades from summer classes taken elsewhere (e.g., at a community college) in a student's GPA, if the student is getting credit for the class. Many high schools, however, do not use grades from off-site classes when calculating the GPA.
So your first step should be to ask your guidance counselor about your school's policy. Presumably, if your school does factor the summer-class grades into your cumulative GPA but you don't want the bio grade to be included, you can tell your counselor that you won't take any credit for the class and it won't be listed on your transcript. It's very possible that your school will allow you to count the calc grade and not the bio grade, but this is something you need to discuss with your counselor.
In theory, you are supposed to report all college-level classes on your applications when you apply to college. But if you don't ask for credit for the bio class and it isn't listed on your transcript, then you can probably “fly under the radar" and not report this bio class on your applications while still reporting the other one. While “The Dean" can't fully endorse this marginally unethical behavior, I personally fee that it's inappropriate for colleges to demand information about a summer class when the class was optional and the student didn't receive any academic credit for it. By expecting students to disclose all summer courses and grades earned, the admission folks may discourage their applicants from taking on academic challenges during their free time ... which I feel is a crummy deal for the student.
In any case, your next stop should be your guidance office to find out about how your school handles summer classes. If you're willing to forego the credit you earned for the summer bio class, your counselor can probably keep it off your transcript, and you can omit the class—and the grade—when you apply to college. Thus the bio class won't have any effect on your GPA or on your college-admission outcomes. But—if you decide not to report it--I can't promise that it won't make at least a tiny dent in your good karma. ;-)